Category Archives: HEMATOLOGY

USE OF CYCLOSPHAMIDE IN AUTOIMMUNE HEMOLYTIC ANEMIA

USE OF CYCLOSPHAMIDE IN AUTOIMMUNE HEMOLYTIC ANEMIA PRELIMINARY Autoimmune hemolytic anemia is anemia that arises due to the formation of autoantibodies against erythrocytes, causing destruction/hemolysis of erythrocytes. The classification of autoimmune hemolytic anemia based on the nature of the antibody … Continue reading

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Cluster of Differentiation 44 (CD44)

Cluster of Differentiation 44 (CD44) PRELIMINARY The adhesion molecule CD44 is a transmembrane glycoprotein that plays a role in lymphocyte activation, recirculation, and balance, extracellular matrix adhesion, angiogenesis, cell proliferation, cell differentiation and cell migration and as a receptor for … Continue reading

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HEMOSTASIS PRIMER

HEMOSTASIS  PRIMER A. INTRODUCTION Maintenance of blood fluidity in the vascular system is an important physiological process in humans. The term ‘hemostasis’ refers to the normal response to injury to a blood vessel by forming a clot that serves to … Continue reading

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NEUTROPHIL AND ITS CLINICAL MEANING

NEUTROPHIL AND ITS CLINICAL MEANING A. Granulopoiesis Leukocytes can be divided into two major groups namely phagocytes and lymphocytes. Phagocytes consist of granulocytes and monocytes. Granulocytes consist of three types of cells namely neutrophils, eosinophils and basophils. Under normal circumstances … Continue reading

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EXTRAVASCULAR HEMOLYSIS

EXTRAVASCULAR HEMOLYSIS PRELIMINARY Hemolytic anemia is anemia caused by the hemolysis process, which is the premature breakdown of erythrocytes in blood vessels. In hemolytic anemia, the lifespan of erythrocytes is shorter (normal erythrocyte lifespan is 100-120 days). Hemolytic anemia is … Continue reading

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SICKLE CELL DISEASE

SICKLE CELL DISEASE preliminary Anemia is generally defined as a reduction in erythrocyte volume or hemoglobin concentration or hematocrit levels below normal values ​​for age so that the ability of the blood to provide oxygen to the tissues is reduced. … Continue reading

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Hemocromatosis dan Hemosiderosis

Hemocromatosis dan Hemosiderosis Iron is a component that is close to the environment of all living things. Iron has an important role in metabolism, especially in electron transfer reactions. Storage of iron in the body is stored in circulating hemoglobin … Continue reading

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COOMB’S TEST

I. COOMB’S TEST BASIC PRINCIPLES Coomb’s test is an examination used to detect the presence of antibodies on the surface of erythrocytes and anti-erythrocyte antibodies in serum. This antibody coats the surface of erythrocytes which causes the lifespan of erythrocytes … Continue reading

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NEUTROPHIL AND ITS CLINICAL MEANING

NEUTROPHIL AND ITS CLINICAL MEANING A. Granulopoiesis Leukocytes can be divided into two major groups namely phagocytes and lymphocytes. Phagocytes consist of granulocytes and monocytes. Granulocytes consist of three types of cells namely neutrophils, eosinophils and basophils. Under normal circumstances … Continue reading

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MONOSITE STRUCTURE AND FUNCTIONS

MONOSITE STRUCTURE AND FUNCTIONS PRELIMINARY White blood cells or leukocytes are a group of diverse cell types that mediate the body’s immunity, circulate through the blood and lymphatic system and are recruited to sites of tissue damage and infection. Leukocytes … Continue reading

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